![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://www.cincinnati.com/gcdn/presto/2021/09/22/PCIN/8ca228a7-f70b-4e10-981f-fd533bddbae0-092121RedsPirates_04.jpg?width=700&height=467&fit=crop&format=pjpg&auto=webp)
Photos: Cincinnati Reds host the Pittsburgh Pirates, 9/21
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://sportsnaut.com/wp-content/uploads/2023/09/21495704.jpg?w=788)
Reds in must-win mode for road series against Guardians
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://cdn.vox-cdn.com/thumbor/fAxZHYHqEiHMpSbrK6vng6g7gjs=/0x0:3670x2447/1200x800/filters:focal(1542x931:2128x1517)/cdn.vox-cdn.com/uploads/chorus_image/image/69890831/1341729002.0.jpg)
Pirates vs. Reds - 9/21/2021 - Bucs Dugout
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://www.playpicks.com/wp-content/uploads/1695399396-post-1148377-kwMnNFa-380x200.jpg)
Reds vs. Pirates Prediction: MLB Betting Lines & Picks - 9/22/2023
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://img.mlbstatic.com/mlb-images/image/upload/ar_16:9,g_auto,q_auto:good,w_1024,c_fill,f_jpg/mlb/cn9iettfxeyohq8gaz04)
Mariners vs. Reds Highlights, 09/05/2023
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://wehco.media.clients.ellingtoncms.com/imports/adg/photos/204652408_204652106-12a4825be4964397b8a017a24290ba11_t800.jpg?90232451fbcadccc64a17de7521d859a8f88077d)
Cincinnati's 11-game streak longest since 1957
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://s7d2.scene7.com/is/image/TWCNews/Reds_cardinals_AP_23143139804382_Ohio_0523)
Reds' streak leaves close to first place in NL Central
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://media.bleacherreport.com/image/upload/c_fill,g_faces,w_1600,h_1600,q_95/v1687806004/ijgwftigmthsaldph9l2.jpg)
MLB Power Rankings: Giants, Reds, Cubs Stay Hot, While Mets Continue to Flounder, News, Scores, Highlights, Stats, and Rumors
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://dims.apnews.com/dims4/default/78b9283/2147483647/strip/true/crop/3437x2291+0+0/resize/599x399!/quality/90/?url=https%3A%2F%2Fassets.apnews.com%2Fc6%2Fcd%2F485d24dcc4c8cfcbc403801adced%2F868cf5570f4a4cc8bb62698d96b2a3f3)
De La Cruz and Maile help the Reds rout the Pirates 9-2 for just their 2nd win in 9 games
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://www.usatoday.com/gcdn/presto/2022/05/15/USAT/b6127469-169a-4a66-8fbf-ae9473c64435-USP_MLB__Cincinnati_Reds_at_Pittsburgh_Pirates.jpg)
Reds vs. Pirates score: Cincinnati no-hits Pittsburgh, still loses
![Pittsburgh Pirates vs. Cincinnati Reds (9/22/21) - MLB](https://cdn.vox-cdn.com/thumbor/se1Hx6hczMSfqIWM11k15oHTJcc=/0x0:3956x2500/1200x800/filters:focal(1645x296:2277x928)/cdn.vox-cdn.com/uploads/chorus_image/image/69893319/1341781133.0.jpg)
Pirates vs. Reds - 9/22/2021 - Bucs Dugout